SBS88 FUNDAMENTALS EXPLAINED

Some strands of Escherichia coli can incorporate the polyketide synthetase (pks) island that encodes colibactin, a genotoxic compound that may alkylate DNA on adenine residues and induce level mutations with a selected signature12,13 (COSMIC SBS88). Also, publicity to pks+ E. coli generates a attribute limited indel signature (COSMIC ID18) which ma